Colossal Biosciences has revived the extinct dire wolf using ancient DNA and gray wolf genes, and is consulting with tribal nations, including the Mandan, Hidatsa and Arikara Nation, to find culturally appropriate homes for the animals. The dire wolf, extinct for over 10,000 years, shares 99.5% of its DNA with the gray wolf, which holds deep cultural and spiritual significance to tribes like the Ojibwe. The company plans no wild release but aims to honor tribal traditions in future reintroductions.